Melancholy

One of the four temperaments in Greek ancient medicine, representing a disease of the mind, body and soul. In Elizabethan England, a common, fashionable though elusive malady, associated with intellect and artistic genius. Among the melancholic figures of the day, Shakespeare's Hamlet is perhaps the most famous, but the condition can also be linked to Romeo, Jacques in As You Like It as well as Don John and Benedick in Much Ado About Nothing.

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Sources: https://shakespeareandbeyond.folger.edu/2021/04/09/renaissance-melancholy-better-than-laughing/ https://www.bl.uk/collection-items/brights-treatise-of-melancholy-1586#:~:text=Melancholy%2C%20the%20'sadde%20and%20fearful,also%20refinement%20and%20male%20intellect. Burton, Robert. The Anatomy of Melancholy (1621)